Despite the fact that the resistance, either to chemotherapy and radiotherapy, of HNSCC cells is due in part to the expression of anti-apoptotic members of the Bcl-2 protein family, including Bcl-XL and Bcl-2 at a lesser extent, the sensitivity of HNSCC to ABT-737, in synergy with cisplatin and etoposide, has only been reported in one work [8]. The gene discussed is BCL2; the disease is head and neck squamous cell carcinoma.