Alternatively, our results also raise the possibility that the manipulation of senescent MSC in vivo via pharmaceutical inhibition of SASP factors like IL-6 or through targeted elimination of these cells, as is now performed in mouse models, could be used in the context of natural aging or of premature aging syndromes [6, 8, 34, 35, 36, 37]. This evidence concerns the gene IL6 and premature aging syndrome.