Examples include the use of soluble Jagged1 to inhibit pulmonary hypertension through its interference with ligand-induced signaling [139], the administration of Notch3-derived peptides to inhibit tumor growth in a pre-clinical model of lung cancer [140], and the use of EGF-like proteins DLK1 and DLK2 as inhibitory ligands of Notch1 [141]. Here, NOTCH1 is linked to neoplasm.