In this context, Nwabo Kamdje et al. have shown that inhibition of both receptors (Notch3 and Notch4) or ligands (Jagged1, Jagged2 and Dll1) in an in vitro BM co-culture system results in B-ALL cell apoptosis, suggesting a potential important role for Notch pathway in mediating the anti-apoptotic effect of BM stromal cells for neoplastic B-cells in the progression of B-ALL [87]. The gene discussed is NOTCH4; the disease is precursor B-cell acute lymphoblastic leukemia.