NOTCH1 and neoplasm: Notch1 is the most studied of the receptors, with a well described oncogenic function in several tissues and as such, it has seen the development of several neutralizing antibodies that have been pre-clinically tested for the treatment of T-ALL and several solid tumors, showing both a direct effect on tumor growth by inhibiting Notch pathway in neoplastic cells and an indirect effect by dysregulating angiogenesis [124–127].