Conditional deletion of Rictor, an mTOR (mammalian target of rapamycin) interacting protein and essential component of the mTORC2 complex, has demonstrated that this complex enables Notch signaling to regulate AKT and NF-κB pathways, promoting thymic T-cell development and T-ALL progression [71]. Here, NFKB1 is linked to acute lymphoblastic leukemia.