Taken together with the other findings discussed here, this suggests that, although AMPK‐α2 might indeed represent a tumour suppressor (similar to its upstream kinase, LKB1), AMPK‐α1 may represent instead an oncogene that is frequently amplified in cancers, perhaps because it protects tumour cells against stresses caused by lack of oxygen or nutrients. The gene discussed is PRKAA2; the disease is cancer.