Because the cancer-risk alleles of the TERT SNPs may contribute to cancer susceptibility by their regulatory effect on TERT expression and telomerase activity [26, 40], it is worth assessing a relationship between TERT risk-alleles and TERT promoter mutations, which likely provides insights into cooperative roles of germline variants and somatic mutations of the TERT gene in oncogenesis. Here, TERT is linked to cancer.