Given the fundamental role of TERT in oncogenesis, much attention has been paid to the association between single nucleotide variants or SNPs of the TERT gene and cancer susceptibility, among which rs2736100 (located in intron 2) is most studied and its variants associated with risk of multiple-types of cancer, as documented by many published reports [4, 5, 7, 20–35]. The gene discussed is TERT; the disease is cancer.