In evaluating the function of AKR1C1/C2 in EDHB-induced ESCC cell death, we showed that LC3-II and Beclin levels were elevated in KYSE 180 cells, which express high AKR1C1/C2 levels, at 12 h after EDHB treatment. The gene discussed is AKR1C1; the disease is esophageal squamous cell carcinoma.