After treatment with siAKR1C1/C2 537 or siAKR1C1/C2 630, the sensitivity of ESCC cells to EDHB was investigated; the EDHB-induced inhibition of cell proliferation was significantly reduced by different siAKR1C1/C2 constructs (Figures 3C and 3D), indicating that AKR1C1/C2 promoted the EDHB-induced inhibition of ESCC cell proliferation. Here, AKR1C1 is linked to esophageal squamous cell carcinoma.