A research group at the Moffitt Cancer Center using mass spectrometric and other high end instrument methodologies has shown, as a part of their studies, that afatinib and dasatinib combine to kill lung cancer cells expressing a mutated active ERBB1, though no actual studies were performed to revert afatinib resistance and in an ERBB1 T790M L858R double mutated receptor cell line [14]. This evidence concerns the gene EGFR and lung carcinoma.