One noticeable difference in the killing of the afatinib H1975 tumor cells between [siERBB3 + si-c-MET + si-c-KIT] and [dasatinib + afatinib] was the relative impact of blocking autophagosome formation and of blocking eIF2α-dependent endoplasmic reticulum stress signaling. Here, EIF2A is linked to neoplasm.