Results showed that risk factors affecting CD4 change 6 months after ART included HCV co-infection, older age, injecting drug use, lower baseline CD4 count, higher HIV viral load, and HIV-1 subtypes 01AE and C. Risk factors affecting viral load suppression to <400 12 months after ART included age, mode of transmission, baseline CD4 count, baseline viral load, ART regimen, prior ART, and HIV-1 subtype C. HBV and HCV co-infection was not associated with virological response. This evidence concerns the gene CD4 and coinfection.