Meanwhile, MVD count determined by CD105 staining in HCC tissues indicated that high SH3BP1 expression group had a significantly higher MVD than that in low SH3BP1 expression group (Figure 5B, 178.6 ± 26.2 vs. 56.3 ± 12.7, P < 0.01, respectively). The gene discussed is ENG; the disease is hepatocellular carcinoma.