In nude mice with HCCLM3 tumor transplantation, the lesion size in the Si-SH3BP1 group was significantly smaller than that in controls (Figure 2D: Top panel, 1.12 ± 0.85 vs. 2.45 ± 0.97 cm3, P < 0.05). This evidence concerns the gene SH3BP1 and neoplasm.