In concordance with the results of the correlation between SH3BP1 expression levels and clinic-pathological indexes obtained in training cohort I, there was a significant association between high SH3BP1 expression and tumor number (P = 0.036), the presence of VI and histological TNM stages in training cohort II (Table 1, P < 0.001). This evidence concerns the gene SH3BP1 and neoplasm.