To address the ability of colon cancer cells, but not other types of cancer cells tested, to internalize calgranulin B present in culture medium, the effects of three endocytosis inhibitors (CPZ for clathrin-mediated endocytosis; MßCD, caveolae/lipid raft-mediated endocytosis; Cyto D, macropinocycosis) were investigated (Figure 3D). This evidence concerns the gene S100A9 and colonic neoplasm.