Furthermore, Ezrin-mediated early metastasis was partially dependent on activation of the ERK/mitogen-activated protein kinase (MAPK) pathway in osteosarcoma [42], while depletion of Ezrin down-regulated the MAPK and transforming growth factor-β pathways in esophageal squamous cell carcinoma [33]. This evidence concerns the gene WNK2 and esophageal squamous cell carcinoma.