LPA is a critical signal transduction molecule and metabolism regulator that promotes tumor progression by modulating cytoskeletal changes, cell-cell contacts, cell survival, proliferation, invasion and metastasis through activating multiple signal pathways, such as HRAS, MAPK, RAC, RHO, PLC, AKT and Hippo-YAP pathways [14–20]. This evidence concerns the gene AKT1 and neoplasm.