Importantly, PLA2G16 expression is associated with poor prognosis and metastasis in human osteosarcoma regardless of p53 status [29], which strongly supports that PLA2G16 play an important role in osteosarcoma progression and metastasis, yet the downstream pathways which mediate the oncogenic function of PLA2G16 in human osteosarcoma remain unknown. The gene discussed is TP53; the disease is osteosarcoma.