The toxicities seen in dose level 1 included grade 3 neutropenia along with grade 1-2 anemia, dermatitis, epistaxis, fatigue, hypercholesterolemia, hyperglycemia, hyperkalemia, hypertriglyceridemia, hypokalema, hypophosphatemia, elevated AST/ALT, renal insufficiency, mucositis/glossitis, nausea, vomiting, proteinuria, fistula, hypomagnesemia and pneumonitis (Table 3). This evidence concerns the gene GPT and anemia.