ATP2B1 and hypertensive disorder: Moreover, in a study by the Japanese Millennium Genome Project, another ATP2B1 variant, rs11105378, was found to have the most significant association with hypertension (P = 4.1 × 10−11), and the association was cross-validated by replication analysis with the Global BPgen dataset (P = 5.9 × 10−4) [1].