Although the pathophysiological implications of ATP2B1 gene on the development of hypertension are still unclear, results from ATP2B1 knockout mouse studies suggested that ATP2B1 may play an important role in the regulation of BP through alterations of calcium handling and vasoconstriction in vascular smooth muscle cells [21]. ATP2B1 mRNA expression levels in umbilical artery smooth muscle cells were found to be significantly different among rs11105378 genotypes, which may be a potential mechanism by which changes in the ATP2B1 gene product levels are involved in BP regulation [1]. The gene discussed is ATP2B1; the disease is Hypertension.