In addition, GSEA revealed ‘carotid artery diseases’ and ‘coronary disease’ in the top 20 of human disease pathways, whereas ‘atherosclerosis signaling’ was found in IPA amongst the top 25 of canonical pathways associated with differentially expressed genes in Nur77-KO versus WT BMM (Fig. 4 and Additional file 1: Table S2). This evidence concerns the gene NR4A1 and coronary artery disorder.