SESN2 and lung adenocarcinoma: To study whether Sesn2 has some protective effects in cancercells, we incubated lung adenocarcinoma SESN2-deficient H1299 cells orSESN2-silenced H460 cells and their control counterparts with glucose-freemedium and found that in both cell lines SESN2 had a significant protectiveeffect against cell death (Fig. 4f,g).