LCN2 and Alzheimer disease: We also focused on four vitamin D-related genes involved in AD commonly dysregulated in the neocortex and hippocampus of Tg animals, namely Lcn2, Ptgs2, Esr1 and Igf1. An overexpression of the transcripts Oxt and Avp is confirmed in the cortex as well as an upregulation of Esr1 in the hippocampus.