The non pathological brain responds to vitamin D3 treatment by modifying the expression of i) nitric oxide in macrophages, ii) neurotrophins and iii) molecules related to Huntington disease whereas the pathological brain reacts by altering the expression of iv) nitric oxide in endothelial cells, v) cathecholamines and vi) molecules associated to Multiple Sclerosis. The gene discussed is BDNF; the disease is Huntington disease.