SMAD3 and osteonecrosis: In summary, we are the first to confirm that miR-708 is inversely correlated with osteonecrosis, and targeting miR-708 can not only promote osteogenic differentiation in vitro, but also can effectively antagonize the suppression of Dex on osteoblast differentiation and adipogenesis differentiation through increasing SMAD3 expression, which may result in the interaction between SMAD3 and RUNX2, and the activation of the TGF-beta signaling pathway.