A series of 8 American HIV positive patients had anti- Tumour Necrosis Factor (anti-TNF) agents (etanercept, adalimumab and infliximab) for different rheumatic conditions (two patients with RA, three with PsA, one with undifferentiated SPA, one with reactive arthritis and one with ankylosing spondylitis) with good efficacy and no adverse effects on their HIV disease [39]. Here, TNF is linked to reactive arthritis.