DSG2 and arrhythmogenic right ventricular cardiomyopathy: Since exome variant calls were unfiltered, there were also a few QVs that were likely to be systematic sequencing errors; these had clear evidence of strand bias and would be easily filtered if a strand bias filter were applied, including a variant rs200691513 (K856N) in the clinically-relevant, ACMG gene DSG2, which is associated with arrhythmogenic right ventricular cardiomyopathy.