The canonical pathways represented by these proteins were liver X receptor/retinoid X receptor (LXR/RXR) and farnesoid X receptor (FXR)/RXR activation, clathrin-mediated endocytosis signaling, atherosclerosis signaling, IL-12 signaling and production in macrophages, nitric oxide and reactive oxygen species production in macrophages, and complement system signaling. The gene discussed is NR1H4; the disease is atherosclerosis.