Forced expression of miR-93 in claudinlow SUM159 and basal HCC1954 cell lines, as well as NOD/SCID mouse xenografts, dramatically reduced the proportion of ALDH+ MET-like breast CSCs and overexpression of miR-100 in breast cancer cell lines and tumor xenografts also modulates the MET and EMT breast CSC states [115]-[116]. The gene discussed is LDHA; the disease is neoplasm.