If MMP-9 is playing a major role in the activation of Neu1 sialidase in complex with EGFR as our data suggest, logistically Snail in inducing MMP-9 in ovarian A2780 cancer cells may be the molecular mechanism(s) by which the Snail-MMP signaling axis functions in tumor neovascularization. This evidence concerns the gene MMP9 and neoplasm.