There is substantial evidence to indicate that the zinc-finger transcriptional factors Snail and Slug, the two-handed zinc factors ZEB-1/dEF1 and ZEB-2/SIP1 and the basic helix-loop-helix transcription factors Twist and E12/E47 play major roles in epithelial carcinoma plasticity [2],[15],[41],[42], and in tumor progression and invasiveness [8],[40],[43],[44]. The gene discussed is TCF3; the disease is neoplasm.