Since the co-expression of EGFR and MMP-9 has prognostic value in cancer [37],[38], and Neu1 and MMP-9 cross-talk regulates EGFRs in pancreatic cancer cells [34], we investigated the molecular targeting potential of the Neu1–MMP9 crosstalk platform in human ovarian cancer cell lines in vitro. This evidence concerns the gene MMP9 and ovarian cancer.