KDR and neoplasm: For A2780 ovarian cancer cells, our data provide additional confirmation for Snail's role in tumor neovascularization, the mechanism(s) of which may involve the Snail-MMP-9 signaling axis in facilitating the signaling paradigm for the activation of growth factor tyrosine kinase receptors through a GPCR-signaling process and MMP-9 activation to induce Neu1 as previously reported by us [33].