Thus, visceral adiposity index (VAI) as a reliable surrogate gender-specific indicator of adipose tissue function and distribution, which comprises simple anthropometric (BMI and WC) and metabolic (triglycerides (TG) and high density lipoprotein-cholesterol (HDL-C)) markers, is implicated in insulin sensitivity, MetS and cardio-metabolic diseases [10–12]. The gene discussed is INS; the disease is metabolic syndrome.