TNF and TNFR1 deficient miceexhibited strongly increased lung weights, an indicator of lung inflammation, 4to 5 weeks post-infection (Fig. 2f–h).Interestingly, TNFR1 deficiency restricted to myeloid cells in M-TNFR1 KO micerecapitulated this increased lung inflammation which was already detectable at 3weeks post-infection (Fig. 2f). This evidence concerns the gene TNF and inflammatory response.