CXCL1/KC levels were increased in M-TNFRI KO already at3–5 weeks post infection, while this was most prominent at 4 weeksfor TNFR1 KO and TNF deficient mice (Fig. 4d).Interestingly, IFNγ, IL-12p40, CXCL1 and IL-1β levelswere elevated in M-TNFR1 KO mice already at 3 weeks post infection, indicativeof an earlier onset of lung inflammation in these mice. The gene discussed is TNF; the disease is infection.