The levels of IFNγ,IL-12/IL-23 p40, IL-1β, CXCL1/KC as well as the expression of CXCR2 wereincreased in the lung of M-TNFR1 KO as compared with TNFR1 KO 3 weekspost-infection, and further increased in both groups at 4–5 weeks. The gene discussed is CXCR2; the disease is infection.