Intriguingly, stimulation with staphylococcal superantigen (staphylococcal enterotoxin B) leads to a Th2‐dominated cytokine profile in circulating CCR6− Tregs of AD patients 12, 14 and there is emerging evidence that Tregs can convert to Th2 cells, thereby contributing to AD instead of dampening the immune response 20. This evidence concerns the gene CCR6 and Alzheimer disease.