In most contexts, such as in melanoma cell lines [27], bladder carcinoma cell lines [28], glioma cells [29], and salivary gland epithelial cells [30], PKC especially PKCα appeared to inhibit apoptosis (except, in the LNCaP prostrate cells in which expression of PKCα promotes apoptosis) [31]. The gene discussed is PRKCA; the disease is melanoma.