To this end, we analyzed the expression of AdipoR1, AdipoR2, AGE, RAGE and GLO-I, focusing on the latter, in a large series of CRC patients with available clinicopathological characteristics and follow up and validated our findings by western immunoblotting in fresh tissue from normal colonic mucosa and CRC tissue, as well as in three colon cancer cell lines. The gene discussed is AGER; the disease is colonic neoplasm.