Here we assess whether MPD suppresses interleukin-1β (IL-1β)- and prostaglandin E2 (PGE2)-induced CGRP release in a cell culture model of trigeminal ganglia cells, which could account for the preventive effect in migraine and cluster headache. Metoprolol﻿(MTP), a migraine preventive with a slow onset of action, was used for comparison. This evidence concerns the gene IL1B and migraine disorder.