The second patient with long-duration disease control had primary estrogen-receptor-positive, HER2-negative papillary carcinoma breast cancer (non-assessable grade, T4N1MX at diagnosis, based on the patient report form) with metastatic disease in a mediastinal lymph node and the liver on study entry, and had received three chemotherapeutic regimens and six hormonal therapies prior to study entry. This evidence concerns the gene ESR1 and breast carcinoma.