PIK3CA and neoplasm: Meanwhile, transfection of cells with constitutively active Akt1 greatly blocked the inhibitory effect of ATR-1 (Fig. 5c, d) as well as the up-regulation of Bax and Bad (Fig. 5b), thereby proving that the anti-tumor effect of ATR-1 relies on the inhibition of PI3K/Akt/mTOR pathway.