Amplification and/or mutations of several key genes regulating this pathway, such as PIK3CA (encoding the p110α subunit), PIK3R1(encoding the p85α subunit), AKT, and PTEN, are well-known mechanisms involved in the activation of PI3K/Akt/mTOR pathway in bladder cancer [17]. This evidence concerns the gene PTEN and urinary bladder carcinoma.