Furthermore, total internal reflection fluorescence microscopy studies have revealed that Rab37 in macrophages is translocated beneath the plasma membrane upon stimulation32, and that Rab37 knockdown in insulinoma cells reduces both, the number of secretory vesicles localised close to the plasma membrane and the frequency of fusion events31, suggesting a role of Rab37 in the docking process. The gene discussed is RAB37; the disease is pancreatic insulinoma.