TIMP1 and cancer: Concerning the impact of cannabinoids on cancer cell spreading, previous findings of our group indicate the anti-invasive effects of several cannabinoids, including R(+)-methanandamide, Δ9-tetrahydrocannabinol as well as cannabidiol to be causally linked to TIMP-1 induction via a mechanism involving activation of cannabinoid receptors and TRPV1 [21, 26, 27].