Our findings demonstrated that both tumor suppressive miRNAs, miR-34a and miR-200c, were upregulated by EGCG which corresponded with downregulation of their target genes MYC, BMI1, and SUZ12. In addition, we showed that the expression of tumor suppressive miR-145 was upregulated by EGCG in 5FUR cells. The gene discussed is SUZ12; the disease is neoplasm.