DLG4 and stroke disorder: In particular, a lower AMPA-NMDA EPSC ratio and an increased number of AMPA silent synapses—as present during the critical period for juvenile OD-plasticity in V1 of WT mice or lifelong in V1 of PSD-95 KO mice [20]–can not only enable a lifelong and juvenile-like OD-plasticity in nonlesioned animals but also protect against impairments of V1-plasticity induced by a distant stroke lesion.