Traditionally, type II ECs are considered to be hormonally independent; there are only limited reports of ER and PR expression (Alkushi et al, 2010; Mhawech-Fauceglia et al, 2013), with no previous data on AR and ERβ expression in serous and clear-cell carcinomas and carcinosarcomas (Hapangama et al, 2015). This evidence concerns the gene ESR2 and clear cell adenocarcinoma.