Unlike breast cancer, the literature on the prognostic value of ERα, ERβ, ERα /ERβ ratio and PR in EC is inconsistent, probably owing to methodological variations (Takama et al, 2001; Fujimoto et al, 2002; Shabani et al, 2007; Jongen et al, 2009; Zannoni et al, 2013). This evidence concerns the gene ESR2 and breast cancer.