Recently, it was shown that cardiomyocytes mediate anti-angiogenic effects in type 2 diabetic rats via the exosomal transfer of miR-320 into endothelial cells where its angiogenesis-related target genes (IGF-1, Hsp20 and Ets2) were down-regulated [71,72]. Here, ETS2 is linked to type 2 diabetes mellitus.