The pathways related to signal transduction pathways (e.g, ErbB, VEGF, TGFβ), immune system (e.g., Fc gamma R-mediated phagocytosis, Leukocyte transendothelial migration, complement and coagulation cascades, T- and B-cell, NOD-like receptor signaling) and endocrine system/metabolic diseases (e.g., Adipocytokine signaling, type I and type-II diabetes), were uniquely represented by up-regulated genes. The gene discussed is EGFR; the disease is Other metabolic disease.