Further comparison of miRNA-mRNA enriched signaling pathways with those enriched by down-regulated mRNAs, identified overlapping pathways related to Apoptosis (e.g., apoptosis, JAK/Stat, Toll-like receptor signaling), Cellular growth/proliferation/development (e.g., Jak/STAT, Gap junction, mTOR), and disease specific pathways (e.g., P53, Pathways in cancer, NSCLC, SCLC, Dilated cardiomyopathy). The gene discussed is TP53; the disease is dilated cardiomyopathy.