In addition to targeting CCND3, hsa-miR-16-5p is also known to regulate the expression of various angiogenic (e.g., PTGS2, VEGF, FGFR) and/or carcinogenic factors (e.g. EGFR, BMP7, MAPKs) with key roles in cancer/disease signaling pathways (Fig 5B). This evidence concerns the gene PTGS2 and cancer.