CDK5 and Parkinson disease: The bioinformatics predictions using GPS 3.0, SCANSITE 3.0 and PhosSNP 1.0 suggested that R1628P mutation could turn its adjacent amino acid residues, serine 1627 (S1627) to a new candidate for phosphorylation by cyclin-dependent kinase 5 (Cdk5), one of the key kinases in the brain which was implicated to be dysregulated in several neurodegenerative diseases, including PD [10, 11] (S1 Fig).