LRRK2 and Parkinson disease: LRRK2 may play a role in the phosphorylation of proteins central to PD, the ezrin/radixin/moesin (ERM) family proteins[13], α-synuclein[14], microtubule-associated protein Tau[15], and Endophilin A[16] have been characterized to be phosphorylated by LRRK2.