A possible way of administering creatine in creatine transporter deficiency could be to modify the creatine molecule in such a way as to create a molecular structure that can cross the BBB and at the same time maintain a biological activity similar to that of creatine (Balestrino et al., 2002). This evidence concerns the gene SLC6A8 and hyperinsulinemic hypoglycemia, familial, 4.