We next investigated miR-154 targets which had been implicated in being involved with liver fibrosis including Dickkopf-related protein 2 (Dkk2)28, Friend leukemia integration-1 (Fli1) that has been implicated in extracellular matrix (ECM) gene regulation in skin fibroblasts29, a novel predicted target involved in calcium transporting, ATPase, Ca++ Transporting, Plasma Membrane 1 (Atp2b1), and cyclin-dependent kinase inhibitor 2B (Cdkn2b), also known as p15, a cell cycle inhibitor shown to be decreased with lung fibrosis20. The gene discussed is FLI1; the disease is Hepatic fibrosis.