BRCA1 and breast cancer: Domchek et al. acquired significantly higher results with respect to breast cancer diagnoses among BRCA1 mutation carriers subjected to prophylactic salpingo-oophorectomy over an almost 5-year-long mean follow-up time – 13.6 % (51/374 – BRCA1). Moreover, quantitative values were comparable regardless of a diagnosis of breast cancer before prophylactic surgery [22].