In recent years, a number of studies have shown that numerous estrogen-responsive genes, including insulin-like growth factor binding protein (IGFBP) family members (IGFBP3, IGFBP4 and IGFBP5), trefoil factor (TFF) family members (TFF1 and TFF3), and TNF receptor-associated protein 1 (TRAP1) among others, affect the growth and development of ovarian cancer [10, 11]. This evidence concerns the gene TRAP1 and ovarian carcinoma.