MCAM and hepatocellular carcinoma: Firstly, the expression of CD146 in HCC tissues and HCC cell lines was detected using RT-PCR and WB, the location of CD146 was confirmed using IHC; Secondly, we established in vitro and in vivo models to investigate the biologic function of CD146 in HCC cells; Thirdly, we conducted a mRNA microarray to systemically explore the mechanism of CD146 induced biologic behavior variation of HCC cells; lastly, CD146 expression and clinical prognosis of HCC patients was concerned.