Moreover, Overexpression of OTUD7B or TNIP2 indeed antagonizes miR-1180-induced NF-κB activation, which further confirmed our conclusion that miR-1180-regulating OTUD7B (or TNIP2)- NF-κB- signaling regulation mediates HCC resistance (Fig. 6f and Supplementary Figure 4). The gene discussed is OTUD7B; the disease is hepatocellular carcinoma.