In summary, the present study demonstrates that the upregulation of miR-1180 contributes to the proliferation and cisplatin-resistance of HCC cells both in vitro and in vivo, by targeting and suppressing OTUD7B, TNIP2 and BAD. Inhibition of OTUD7B and TNIP2 results in activation of NF-κB, suggesting the anti-apoptotic function of miR-1180 may occur through the NF-κB signaling pathway. The gene discussed is TNIP2; the disease is hepatocellular carcinoma.