Currently, in addition to BRAF inhibitors (e.g., Vemurafenib and Dabrafenib), several other targeted inhibitors, including MEK inhibitors (e.g., Trametinib and Cobimetinib) and PI3K inhibitors (e.g., BEZ235), are being evaluated in clinical trials for treatment of melanoma patients. The gene discussed is MAP2K7; the disease is melanoma.