Figure S2F shows the survival percentage of 100 cancer patients undergoing BRAF-I treatment from 0 to 360 days compared with no treatment controls. Our simulation demonstrated that treatment with BRAF-I significantly prolonged progression-free survival in melanoma patients harboring BRAF mutations. This result is consistent with clinical studies of melanoma patients harboring the BRAF V600E mutation45, 49. This evidence concerns the gene BRAF and melanoma.