Autoimmune responses to some HSPs, including Mycobacterial (Myc) HSP65 and Binding Immunoglobulin protein (BiP), a member of the HSP70 family, have been reported in RA, and the induction of tolerance to these HSPs has been investigated as a new therapeutic approach against this disease5, 6. The gene discussed is HSPA5; the disease is rheumatoid arthritis.