It has been suggested that SNPs in CNFL genes (including rs3027178 in PER1, rs228669 and rs2640908 in PER3, and rs3809236 in CRY1) confer susceptibility to various cancers, just as prostate cancer15, breast cancer34, non-Hodgkin’s lymphoma35, and liver cancer14, 16. This evidence concerns the gene PER3 and cancer.