BRAF and melanoma: High percentages of melanoma tumor cells show mutations in the BRAF locus [35] Due to the fact, that in melanoma hyper-activated BRAF often suppresses MITF [13–17], we compared the BRAF mutation status with the expression of MITF, SOX10 and SOX5. Investigating the SKCM dataset, SOX10 and MITF expression tended to be higher in melanoma samples with normal BRAF (p = 0.06 and p = 0.08, two sided Student’s T-test).