Venetoclax (ABT-199) is a specific oral B-cell lymphoma 2 (Bcl-2) inhibitor currently in clinical trials for the treatment of chronic lymphatic leukemia (CLL), acute myelogenous leukemia, small lymphocytic lymphomas, and multiple myeloma [1,2,3]. The gene discussed is BCL2; the disease is B-cell chronic lymphocytic leukemia.